Bos taurus Gene: BT.103474
Summary
InnateDB Gene IDBG-636898.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.103474
Gene Name caspase-2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018159
Encoded Proteins
caspase-2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Nlrp3 and Casp2 are required for endoplasmic reticulum stress-induced inflammation.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106144:
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer\'s disease, Huntington\'s disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:107494887-107511647
Strand Forward strand
Band
Transcripts
ENSBTAT00000024166 ENSBTAP00000024166
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.
Predicted by orthology
Total 35 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0016787 hydrolase activity
GO:0019904 protein domain specific binding
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
Biological Process
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0016485 protein processing
GO:0035234 ectopic germ cell programmed cell death
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0071260 cellular response to mechanical stimulus
GO:0097190 apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathway Predictions based on Human Orthology Data
NETPATH
TNFalpha pathway
REACTOME
Signalling by NGF pathway
Innate Immune System pathway
p75 NTR receptor-mediated signalling pathway
Signal Transduction pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
NOD1/2 Signaling Pathway pathway
Immune System pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
NADE modulates death signalling pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
NADE modulates death signalling pathway
Signalling by NGF pathway
Signal Transduction pathway
p75 NTR receptor-mediated signalling pathway
KEGG
INOH
PID BIOCARTA
Internal ribosome entry pathway [Biocarta view]
Tnfr1 signaling pathway [Biocarta view]
Hiv-1 nef: negative effector of fas and tnf [Biocarta view]
Tnf/stress related signaling [Biocarta view]
Caspase cascade in apoptosis [Biocarta view]
PID NCI
Caspase Cascade in Apoptosis
p73 transcription factor network
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Cross-References
SwissProt
TrEMBL E1BJT6
UniProt Splice Variant
Entrez Gene 531419
UniGene Bt.103474
RefSeq NM_001144104 XM_005205863 XM_005205864
HUGO HGNC:1503
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02011802
GenPept
RNA Seq Atlas 531419
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

(Move your mouse over the image to view a more detailed version)