Homo sapiens Gene: CASP2
Summary
InnateDB Gene IDBG-45836.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CASP2
Gene Name caspase 2, apoptosis-related cysteine peptidase
Synonyms CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57;
Species Homo sapiens
Ensembl Gene ENSG00000106144
Encoded Proteins
caspase 2, apoptosis-related cysteine peptidase
caspase 2, apoptosis-related cysteine peptidase
caspase 2, apoptosis-related cysteine peptidase
caspase 2, apoptosis-related cysteine peptidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Nlrp3 and Casp2 are required for endoplasmic reticulum stress-induced inflammation.
Entrez Gene
Summary This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer\'s disease, Huntington\'s disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:143288215-143307696
Strand Forward strand
Band q34
Transcripts
ENST00000310447 ENSP00000312664
ENST00000350623 ENSP00000340030
ENST00000392925 ENSP00000376656
ENST00000493642
ENST00000481483
ENST00000472067
ENST00000619992 ENSP00000481929
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 42 [view]
Protein-Protein 35 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 5 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0005515 protein binding
GO:0008234 cysteine-type peptidase activity
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
Biological Process
GO:0001554 luteolysis
GO:0003407 neural retina development
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007420 brain development
GO:0007568 aging
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0016485 protein processing
GO:0035234 ectopic germ cell programmed cell death
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0071260 cellular response to mechanical stimulus
GO:0097190 apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097194 execution phase of apoptosis
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
TNFalpha pathway
REACTOME
Signalling by NGF pathway
Innate Immune System pathway
p75 NTR receptor-mediated signalling pathway
Signal Transduction pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
NOD1/2 Signaling Pathway pathway
Immune System pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
NADE modulates death signalling pathway
KEGG
INOH
PID BIOCARTA
Internal ribosome entry pathway [Biocarta view]
Tnfr1 signaling pathway [Biocarta view]
Hiv-1 nef: negative effector of fas and tnf [Biocarta view]
Tnf/stress related signaling [Biocarta view]
Caspase cascade in apoptosis [Biocarta view]
PID NCI
Caspase Cascade in Apoptosis
p73 transcription factor network
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.368982 Hs.593257
RefSeq NM_032982 NM_032983
HUGO
OMIM
CCDS CCDS47733 CCDS5879
HPRD 02800
IMGT
EMBL
GenPept
RNA Seq Atlas