Version 5.4
Homo sapiens Gene: IKBKB
Summary
InnateDB Gene IDBG-19987.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IKBKB
Gene Name inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Synonyms IKK-beta; IKK2; IKKB; IMD15; NFKBIKB;
Species Homo sapiens
Ensembl Gene ENSG00000104365
Encoded Proteins
IDBP-19989
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IDBP-369376
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IDBP-476251
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IDBP-482624
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IDBP-478023
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IDBP-475692
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IDBP-482607
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IDBP-483525
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IDBP-477372
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IDBP-473430
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IDBP-484482
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IDBP-477745
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IDBP-482801
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IDBP-474779
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IDBP-475293
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IDBP-479708
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IDBP-473869
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18692471
IKBKB regulates late-phase allergic reactions promoted by the release of pro-inflammatory cytokines in an NF-kappaB-dependent manner.
PMID 20627395
Phosphorylated IKBKB is conjugated with a monoubiquitin by the E3 ubiquitin ligase TRIM21 leading to down-regulatioin of IKBKB-induced NF-kappaB signalling. The TRIM21-mediated monoubiquitination is involved in the translocation of active IKBKB to autophagosomes.
PMID 21138416
IKBKB and other IKK kinases regulate each other by an intricate network involving phosphorylation of their catalytic and regulatory (NEMO, TANK) subunits to balance their activities during innate immunity.
PMID 24323043
GNB2L1 (RACK1) negatively regulates NFκB activation by interacting with CHUK and IKBKB. The interaction interferes with the recruitment of the IKK complex to TRAF2 .
PMID 26620909
The reversible ubiquitin editing of NLRC5 determines NLRC5â?? IKBKB interaction dynamics and plays a crucial role in precisely regulating NFκB signalling
PMID 26394554
Enterovirus 71 2C protein binds to RELA and IKBKB to inhibit NF-kB activation and evade innate immune defenses.
InnateDB Annotation from Orthologs
Summary
PMID 21138416
[Mus musculus] Ikbkb and other IKK kinases regulate each other by an intricate network involving phosphorylation of their catalytic and regulatory (NEMO, TANK) subunits to balance their activities during innate immunity.
PMID 26620909
[Mus musculus] The reversible ubiquitin editing of Nlrc5 determines Nlrc5â?? Ikbkb interaction dynamics and plays a crucial role in precisely regulating NFκB signalling
Entrez Gene
Summary The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:42271302-42332653
Strand Forward strand
Band p11.21
Transcripts
ENST00000342222 ENSP00000339151
ENST00000416505 ENSP00000404920
ENST00000520810 ENSP00000430684
ENST00000520320 ENSP00000429699
ENST00000517890 ENSP00000428799
ENST00000519733 ENSP00000429319
ENST00000519735 ENSP00000430483
ENST00000523105 ENSP00000429239
ENST00000520835 ENSP00000430868
ENST00000517917
ENST00000518679 ENSP00000430557
ENST00000518983 ENSP00000427978
ENST00000520201
ENST00000517388 ENSP00000429924
ENST00000518647
ENST00000521661 ENSP00000428186
ENST00000520655 ENSP00000428922
ENST00000517812 ENSP00000429357
ENST00000522147 ENSP00000428892
ENST00000523517 ENSP00000430114
ENST00000522545
ENST00000517502
ENST00000522785
ENST00000519938
ENST00000522133
ENST00000523018
ENST00000523599
ENST00000521225
ENST00000522103
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 300 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.
Experimentally validated
Total 300 [view]
Protein-Protein 297 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 1 [view]
DNA-RNA 0
Predicted by orthology
Total 42 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008384 IkappaB kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0019901 protein kinase binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0097110 scaffold protein binding
Biological Process
GO:0001782 B cell homeostasis
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006468 protein phosphorylation
GO:0006954 inflammatory response
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007252 I-kappaB phosphorylation
GO:0009103 lipopolysaccharide biosynthetic process
GO:0009615 response to virus
GO:0010765 positive regulation of sodium ion transport
GO:0032481 positive regulation of type I interferon production
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0042501 serine phosphorylation of STAT protein
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050852 T cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0071356 cellular response to tumor necrosis factor
GO:2001259 positive regulation of cation channel activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0008385 IkappaB kinase complex
GO:0009898 cytoplasmic side of plasma membrane
GO:0016020 membrane
GO:0035631 CD40 receptor complex
GO:0045121 membrane raft
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSMUSG00000031537
View Gene Order
Ortholuge
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
ENSBTAG00000007599
Not yet available
Ortholuge
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
NetPath_7
TGF_beta_Receptor pathway
NetPath_9
TNFalpha pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_13
IL1 pathway
NetPath_16
IL4 pathway
NetPath_21
RANKL pathway
NetPath_22
Leptin pathway
NetPath_23
TSH pathway
NetPath_26
TWEAK pathway
NetPath_147
IL11 pathway
REACTOME
REACT_118563
RIP-mediated NFkB activation via ZBP1 pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_163994
FCERI mediated NF-kB activation pathway
REACT_11061
Signalling by NGF pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_13415
p75NTR recruits signalling complexes pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_12526
TCR signaling pathway
REACT_118764
ZBP1(DAI) mediated induction of type I IFNs pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_6802
Innate Immune System pathway
REACT_13696
NF-kB is activated and signals survival pathway
REACT_25374
IKK complex recruitment mediated by RIP1 pathway
REACT_24918
IRAK1 recruits IKK complex pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_24969
TRAF6 mediated NF-kB activation pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_13537
p75NTR signals via NF-kB pathway
REACT_25359
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_111102
Signal Transduction pathway
REACT_25354
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation pathway
REACT_25039
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 pathway
REACT_118656
Activation of NF-kappaB in B cells pathway
REACT_75913
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
REACT_75774
Adaptive Immune System pathway
REACT_75776
NOD1/2 Signaling Pathway pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_6900
Immune System pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_22232
Signaling by Interleukins pathway
REACT_12555
Downstream TCR signaling pathway
REACT_22442
Interleukin-1 signaling pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_118823
Cytosolic sensors of pathogen-associated DNA pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_21281
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
KEGG
hsa04010
MAPK signaling pathway pathway
hsa04062
Chemokine signaling pathway pathway
hsa04150
mTOR signaling pathway pathway
hsa04210
Apoptosis pathway
hsa04380
Osteoclast differentiation pathway
hsa04620
Toll-like receptor signaling pathway pathway
hsa04621
NOD-like receptor signaling pathway pathway
hsa04622
RIG-I-like receptor signaling pathway pathway
hsa04623
Cytosolic DNA-sensing pathway pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04662
B cell receptor signaling pathway pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04910
Insulin signaling pathway pathway
hsa04920
Adipocytokine signaling pathway pathway
hsa04930
Type II diabetes mellitus pathway
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
hsa05131
Shigellosis pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa05145
Toxoplasmosis pathway
hsa05160
Hepatitis C pathway
hsa05200
Pathways in cancer pathway
hsa05212
Pancreatic cancer pathway
hsa05215
Prostate cancer pathway
hsa05220
Chronic myeloid leukemia pathway
hsa05221
Acute myeloid leukemia pathway
hsa05222
Small cell lung cancer pathway
INOH
INOH website
TNFR1 signaling pathway pathway
INOH website
IL-7 signaling pathway
INOH website
CD4 T cell receptor signaling pathway
INOH website
IL-1 signaling pathway pathway
INOH website
Toll-like receptor signaling pathway pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
B cell receptor signaling pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID BIOCARTA
100013
Toll-like receptor pathway [Biocarta view]
100016
Chaperones modulate interferon signaling pathway [Biocarta view]
100097
Nf-kb signaling pathway [Biocarta view]
100221
Role of egf receptor transactivation by gpcrs in cardiac hypertrophy [Biocarta view]
100152
Inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages [Biocarta view]
100119
Keratinocyte differentiation [Biocarta view]
100052
Bone remodeling [Biocarta view]
100040
Double stranded rna induced gene expression [Biocarta view]
100018
Trefoil factors initiate mucosal healing [Biocarta view]
100132
Signal transduction through il1r [Biocarta view]
100026
Tnf/stress related signaling [Biocarta view]
100113
Mapkinase signaling pathway [Biocarta view]
100206
Ceramide signaling pathway [Biocarta view]
100088
Nfkb activation by nontypeable hemophilus influenzae [Biocarta view]
100054
Influence of ras and rho proteins on g1 to s transition [Biocarta view]
PID NCI
nfkappabatypicalpathway
Atypical NF-kappaB pathway
cd8tcrpathway
TCR signaling in naïve CD8+ T cells
tcr_pathway
TCR signaling in naïve CD4+ T cells
il1pathway
IL1-mediated signaling events
tnfpathway
TNF receptor signaling pathway
trail_pathway
TRAIL signaling pathway
mtor_4pathway
mTOR signaling pathway
foxopathway
FoxO family signaling
p75ntrpathway
p75(NTR)-mediated signaling
bcr_5pathway
BCR signaling pathway
nfkappabcanonicalpathway
Canonical NF-kappaB pathway
gmcsf_pathway
GMCSF-mediated signaling events
tap63pathway
Validated transcriptional targets of TAp63 isoforms
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
toll_endogenous_pathway
Endogenous TLR signaling
faspathway
FAS (CD95) signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.597664 Hs.715799
RefSeq NM_001190720 NM_001242778 NM_001556 XM_005273492
HUGO
OMIM
CCDS CCDS55228 CCDS56535 CCDS6128
HPRD 04462
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca