Version 5.4
Mus musculus Gene: Stat1
Summary
InnateDB Gene IDBG-153162.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Stat1
Gene Name signal transducer and activator of transcription 1
Synonyms 2010005J02Rik; AA408197;
Species Mus musculus
Ensembl Gene ENSMUSG00000026104
Encoded Proteins
IDBP-153164
signal transducer and activator of transcription 1
IDBP-788911
signal transducer and activator of transcription 1
IDBP-788914
signal transducer and activator of transcription 1
IDBP-788915
signal transducer and activator of transcription 1
IDBP-788916
signal transducer and activator of transcription 1
IDBP-788917
signal transducer and activator of transcription 1
IDBP-788920
signal transducer and activator of transcription 1
IDBP-788921
signal transducer and activator of transcription 1
IDBP-788923
signal transducer and activator of transcription 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22065572
Stat1 phosphorylation at Ser708 is a key event in the IFN signalling pathway that imparts anti-viral immunity to restrict West Nile virus infection.
PMID 22425562
Histone deacetylase inhibitors prevent Ifng-mediated phosphorylation of Stat1. (Demonstrated in human)
PMID 25431490
Il28ra (Ifnlr1), Stat1 and Irf3 are required for antibiotics to prevent persistent murine norovirus infection.
PMID 25972472
Cd81 inhibits Rac1/Stat1 activation and negatively regulates the defence mechanisms to Listeria monocytogenes infection.
PMID 25848864
Treml4 is an essential positive regulator of Tlr7 signalling. Treml4(-/-) macrophages are hyporesponsive to Tlr7 agonists and fail to produce type I interferons due to impaired phosphorylation of Stat1 by Mapk14 and decreased recruitment of Myd88 to Tlr7.
PMID 26335850
Transcriptional activation of Adar by IFN occurs in the absence of Stat1 by a non-canonical Stat2-dependent pathway.
InnateDB Annotation from Orthologs
Summary
PMID 17971840
[Homo sapiens] STAT1 mediates IFNG cytokine signalling, and as a member of the STAT family protein, STAT1 has a significant impact on the innate immunity during sepsis.
PMID 18678606
[Homo sapiens] STAT1 serine phosphorylation is induced by TNF-alpha and PGE2 and this activates expression of the STAT1 and NF-kappaB target gene IFN regulatory factor 1 (IRF1), which contributes to IFN responses.
PMID 7657660
[Homo sapiens] STAT1 phosphorylation and DNA binding activity is under the control of Janus protein-tyrosine kinases (JAKs) and the epidermal growth factor receptor (EGFR).
PMID 16481475
[Homo sapiens] Acetylation of STAT1 modulates NF-kappaB activity and thus ultimately apoptosis where, as a result, RELA DNA binding, nuclear localization, and expression of anti-apoptotic NF-kappaB target genes decrease.
PMID 8943351
[Homo sapiens] STAT1 is part of the interferon-stimulated gene factor 3 (ISGF3) transcription complex which is composed of a STAT1:2 heterodimer and a weak DNA-binding protein, IRF9.
PMID 20829351
[Homo sapiens] STAT1 transcription factor enhances TLR8 functionality by binding of to GAS elements on the TLR8 promoter in an IFN-gamma-dependent manner.
PMID 22065572
[Homo sapiens] STAT1 phosphorylation at Ser708 is a key event in the IFN signalling pathway that imparts anti-viral immunity to restrict West Nile virus infection. (Demonstrated in mice)
PMID 22425562
[Homo sapiens] Histone deacetylase inhibitors prevent IFNG-mediated phosphorylation of STAT1.
PMID 24449862
[Homo sapiens] TNK1 is a component of the IFN-JAK-STAT signalling cascade and is a critical antiviral host factor where its abundance is inversely correlated to viral replication and contributes to the hepatocytic response to antiviral treatment.
PMID 25027037
[Homo sapiens] STAT1 is directly recruited to TRAF6, demonstrating cross-talk between the TLR and JAK/STAT signalling pathways, and this direct activation of STAT1 by TLR signalling suggests a crucial role for STAT1 in TLR-induced inflammation. Demonstrated in mice.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115415:
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:52119440-52161865
Strand Forward strand
Band C1.1
Transcripts
ENSMUST00000070968 ENSMUSP00000066743
ENSMUST00000186574 ENSMUSP00000140518
ENSMUST00000191435 ENSMUSP00000139746
ENSMUST00000186857 ENSMUSP00000140875
ENSMUST00000188681 ENSMUSP00000141144
ENSMUST00000189347 ENSMUSP00000141125
ENSMUST00000186186
ENSMUST00000185743
ENSMUST00000186057 ENSMUSP00000141132
ENSMUST00000189075
ENSMUST00000189244 ENSMUSP00000140482
ENSMUST00000189336 ENSMUSP00000140643
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 78 experimentally validated interaction(s) in this database.
They are also associated with 174 interaction(s) predicted by orthology.
Experimentally validated
Total 78 [view]
Protein-Protein 29 [view]
Protein-DNA 49 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 174 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0000983 RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004871 signal transducer activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0031730 CCR5 chemokine receptor binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001937 negative regulation of endothelial cell proliferation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0007259 JAK-STAT cascade
GO:0007584 response to nutrient
GO:0008015 blood circulation
GO:0008284 positive regulation of cell proliferation
GO:0009612 response to mechanical stimulus
GO:0009617 response to bacterium
GO:0014070 response to organic cyclic compound
GO:0016525 negative regulation of angiogenesis
GO:0019221 cytokine-mediated signaling pathway
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032496 response to lipopolysaccharide
GO:0032869 cellular response to insulin stimulus
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034097 response to cytokine
GO:0034240 negative regulation of macrophage fusion
GO:0035458 cellular response to interferon-beta
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043330 response to exogenous dsRNA
GO:0043434 response to peptide hormone
GO:0045087 innate immune response (InnateDB)
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051591 response to cAMP
GO:0061326 renal tubule development
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0030424 axon
GO:0030425 dendrite
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
Method
Confidence
Comments
ENSG00000115415
View Gene Order
RBBH
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
KEGG
mmu04062
Chemokine signaling pathway pathway
mmu04380
Osteoclast differentiation pathway
mmu04620
Toll-like receptor signaling pathway pathway
mmu04630
Jak-STAT signaling pathway pathway
mmu05140
Leishmaniasis pathway
mmu05145
Toxoplasmosis pathway
mmu05160
Hepatitis C pathway
mmu05200
Pathways in cancer pathway
mmu05212
Pancreatic cancer pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
NetPath_9
TNFalpha pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_14
IL2 pathway
NetPath_16
IL4 pathway
NetPath_17
IL5 pathway
NetPath_18
IL6 pathway
NetPath_19
IL-7 pathway
NetPath_20
IL9 pathway
NetPath_21
RANKL pathway
NetPath_22
Leptin pathway
NetPath_23
TSH pathway
NetPath_24
TSLP pathway
NetPath_56
Prolactin pathway
NetPath_147
IL11 pathway
NetPath_114
Oncostatin_M pathway
REACTOME
REACT_120736
Signaling by FGFR in disease pathway
REACT_121398
Signaling by FGFR mutants pathway
REACT_115676
Antiviral mechanism by IFN-stimulated genes pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_120999
Signaling by FGFR1 mutants pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_111102
Signal Transduction pathway
REACT_25229
Interferon Signaling pathway
REACT_6900
Immune System pathway
REACT_17025
Downstream signal transduction pathway
REACT_115831
ISG15 antiviral mechanism pathway
REACT_16888
Signaling by PDGF pathway
REACT_121141
Signaling by FGFR1 fusion mutants pathway
REACT_116125
Disease pathway
KEGG
hsa04062
Chemokine signaling pathway pathway
hsa04380
Osteoclast differentiation pathway
hsa04620
Toll-like receptor signaling pathway pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa05140
Leishmaniasis pathway
hsa05145
Toxoplasmosis pathway
hsa05160
Hepatitis C pathway
hsa05200
Pathways in cancer pathway
hsa05212
Pancreatic cancer pathway
INOH
INOH website
IFN gamma signaling pathway
INOH website
IFN alpha signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
IL-5 signaling pathway
PID BIOCARTA
100154
Inhibition of cellular proliferation by gleevec [Biocarta view]
100139
Ifn alpha signaling pathway [Biocarta view]
100077
Pdgf signaling pathway [Biocarta view]
100085
P38 mapk signaling pathway [Biocarta view]
100131
Il22 soluble receptor signaling pathway [Biocarta view]
100012
Tpo signaling pathway [Biocarta view]
100226
Bioactive peptide induced signaling pathway [Biocarta view]
100113
Mapkinase signaling pathway [Biocarta view]
100181
Egf signaling pathway [Biocarta view]
100138
Ifn gamma signaling pathway [Biocarta view]
PID NCI
il2_1pathway
IL2-mediated signaling events
il27pathway
IL27-mediated signaling events
tnfpathway
TNF receptor signaling pathway
il12_2pathway
IL12-mediated signaling events
erbb1_downstream_pathway
ErbB1 downstream signaling
epopathway
EPO signaling pathway
reg_gr_pathway
Glucocorticoid receptor regulatory network
fgf_pathway
FGF signaling pathway
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
tcptp_pathway
Signaling events mediated by TCPTP
il23pathway
IL23-mediated signaling events
shp2_pathway
SHP2 signaling
pdgfrbpathway
PDGFR-beta signaling pathway
il6_7pathway
IL6-mediated signaling events
ifngpathway
IFN-gamma pathway
Cross-References
SwissProt
TrEMBL Q8C3V4 Q99K94
UniProt Splice Variant
Entrez Gene 20846
UniGene Mm.277406 Mm.401800
RefSeq NM_001205314 NM_009283 XM_006495811 XM_006495812 NM_001205313 XM_006495813
OMIM
CCDS CCDS56628
HPRD
IMGT
MGI ID MGI:103063
MGI Symbol Stat1
EMBL AC123752 AK039458 AK084855 AK157263 BC004808 CH466548
GenPept AAH04808 BAC30355 BAC39293 BAE34017 EDK99968
RNA Seq Atlas 20846

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca